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The Potent Effects of Kambo and Ayahuasca in a Single Retreat Program

Updated: Sep 3, 2023

Ayahuasca and Kambo are two plant-based medicines that have been used in traditional healing practices for centuries. Ayahuasca, also known as yage, is made from a combination of the ayahuasca vine (Banisteriopsis caapi) and the leaves of the chacruna plant (Psychotria viridis). Kambo, on the other hand, is made from the secretions of the giant monkey frog (Phyllomedusa bicolor).




Ayahuasca contains a mixture of alkaloids, including dimethyltryptamine (DMT), which is a potent psychoactive compound that can induce altered states of consciousness. Ayahuasca also contains harmala alkaloids, which inhibit the breakdown of DMT in the body, leading to longer-lasting effects. Ayahuasca has been studied for its potential therapeutic effects in treating depression, anxiety, and addiction.


Kambo contains peptides that can have various physiological effects on the body. These peptides have been found to stimulate the immune system, increase circulation, and help with pain relief. Kambo has also been studied for its potential anti-inflammatory and anti-cancer properties.


In a randomized controlled trial, Ayahuasca was found to have significant antidepressant effects in a group of patients with treatment-resistant depression. Ayahuasca has also been found to increase the functional connectivity between brain regions involved in emotional processing and self-referential thinking. Ayahuasca has been shown to increase the expression of genes related to neuroplasticity and synaptic function, potentially indicating a mechanism for its therapeutic effects. Ayahuasca has also been found to increase the proliferation and differentiation of neural stem cells in vitro, potentially indicating a neuroregenerative effect.


Kambo has been found to have potent antimicrobial activity against various bacteria, including Staphylococcus aureus and Escherichia coli. Kambo has been shown to increase the production of cytokines, such as interleukin-6 and tumor necrosis factor-alpha, which are involved in immune system function and inflammation. Kambo has been found to have potent analgesic effects, potentially due to the presence of opioid peptides. Kambo has also been studied for its potential anti-cancer properties, with some studies suggesting that it may have the ability to inhibit the growth of cancer cells.


Therefore, the combination of Ayahuasca and Kambo in a retreat program can provide complementary healing effects. Ayahuasca is known for its psychological and spiritual effects, while Kambo is used for physical detoxification and immune system stimulation. The combination can lead to a more comprehensive healing experience by using Kambo to perform large scale detoxification which clears space for Ayahuasca to move more effectively through the physical, mental, emotional and energetic bodies. What can be achieved in one program using both medicines together can have a greater and more positive impact than using only one medicine.


However, it is important to work with experienced facilitators and practitioners who can provide proper guidance and support throughout the process. While the combination of Ayahuasca and Kambo in a retreat program can offer potential benefits, it is important to consider the potential risks and work with experienced practitioners who can provide proper guidance and support throughout the process. It is also important to inform facilitators of any medications you are taking before participating in a retreat program to avoid any potential interactions.


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